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Table 2: Adverse reactions in sufferers handled with pembrolizumab* Monotherapy Combination with Combination with chemotherapy axitinib Infections and infestations Common pneumonia pneumonia pneumonia Blood and lymphatic system problems Very common anaemia anaemia, neutropaenia, thrombocytopaenia Common thrombocytopaenia, febrile neutropaenia, anaemia, neutropaenia, lymphopaenia leukopaenia, leukopaenia, lymphopaenia thrombocytopaenia Uncommon neutropaenia, leukopaenia, lymphopaenia, eosinophilia eosinophilia Rare immune thrombocytopenic eosinophilia purpura, haemolytic anaemia, pure red cell aplasia, haemophagocytic lymphohistiocytosis Immune system issues a a Common infusion related response infusion associated reaction infusion associated a response Uncommon sarcoidosis Not identified stable organ transplant rejection Endocrine disorders b Very widespread hypothyroidism hyperthyroidism, b hypothyroidism d Common hyperthyroidism hypothyroidism, hypophysitis, e hyperthyroidism thyroiditis, adrenal c insufficiency c d Uncommon adrenal insufficiency, hypophysitis, d e e hypophysitis, thyroiditis thyroiditis, adrenal c insufficiency 12 Metabolism and nutrition problems Very widespread decreased urge for food hypokalaemia, decreased decreased appetite urge for food Common hyponatraemia, hyponatraemia, hypokalaemia, hypokalaemia, hypocalcaemia hyponatraemia, hypocalcaemia hypocalcaemia f f Uncommon sort 1 diabetes mellitus sort 1 diabetes mellitus type 1 diabetes mellitus Psychiatric issues Common insomnia insomnia insomnia Nervous system disorders Very frequent headache dizziness, headache, headache, dysgeusia neuropathy peripheral, dysgeusia Common dizziness, neuropathy lethargy dizziness, lethargy, peripheral, lethargy, neuropathy peripheral dysgeusia h Uncommon epilepsy epilepsy myasthenic syndrome g Rare Guillain-Barre syndrome, h myasthenic syndrome, i meningitis (aseptic), encephalitis Eye issues Common dry eye dry eye dry eye j j Uncommon uveitis uveitis Rare Vogt-Koyanagi-Harada syndrome Cardiac disorders пїЅ пїЅ пїЅ Common cardiac arrhythmia cardiac arrhythmia cardiac arrhythmia (including atrial (including atrial (including atrial fibrillation) fibrillation) fibrillation) ok Uncommon pericardial effusion, pericardial effusion myocarditis pericarditis k ok Rare myocarditis myocarditis, pericarditis Vascular problems Very frequent hypertension Common hypertension hypertension Respiratory, thoracic and mediastinal issues Very frequent dyspnoea, cough dyspnoea, cough dyspnoea, cough, dysphonia l l l Common pneumonitis pneumonitis pneumonitis Gastrointestinal problems Very common diarrhoea, belly diarrhoea, nausea, diarrhoea, stomach m m pain, nausea, vomiting, vomiting, constipation, pain, nausea, vomiting, m constipation belly ache constipation n n n Common colitis, dry mouth colitis, dry mouth colitis, dry mouth o o o Uncommon pancreatitis pancreatitis pancreatitis Rare small intestinal perforation Hepatobiliary disorders p Common hepatitis p p Uncommon hepatitis hepatitis Skin and subcutaneous tissue issues q r q r Very common rash, pruritus rash, alopecia, pruritus palmar-plantar erythrodysaesthesia q syndrome, rash, r pruritus 13 s s s Common severe skin reactions, extreme skin reactions, severe skin reactions, erythema, dry skin, erythema, dry skin dermatitis acneiform, t vitiligo, eczema, alopecia, dermatitis, dry pores and skin, dermatitis acneiform alopecia, eczema, erythema u Uncommon lichenoid keratosis, psoriasis, dermatitis hair colour adjustments, psoriasis, dermatitis, acneiform, dermatitis, lichenoid keratosis, t papule, hair colour adjustments vitiligo, eczema papule, psoriasis, t vitiligo Rare poisonous epidermal necrolysis, hair color adjustments, Stevens-Johnson syndrome, lichenoid keratosis, erythema nodosum papule Musculoskeletal and connective tissue disorders v v v Very frequent musculoskeletal pain, musculoskeletal pain, musculoskeletal pain, arthralgia arthralgia arthralgia, ache in extremity w w x Common pain in extremity, myositis, ache in myositis, arthritis, w x x y myositis, arthritis extremity, arthritis tenosynovitis y y Uncommon tenosynovitis tenosynovitis Renal and urinary issues z Common nephritis, acute kidney acute kidney injury, z harm nephritis z Uncommon nephritis General disorders and administration site situations aa Very common fatigue, asthenia, oedema, fatigue, asthenia, pyrexia, fatigue, asthenia, aa pyrexia oedema pyrexia aa Common influenza-like sickness, chills chills, influenza-like oedema, influenza-like sickness illness, chills Investigations Very common blood creatinine alanine increased aminotransferase elevated, aspartate aminotransferase increased, blood creatinine elevated Common aspartate aminotransferase hypercalcaemia, alanine blood alkaline elevated, alanine aminotransferase phosphatase elevated, aminotransferase elevated, increased, aspartate hypercalcaemia, blood hypercalcaemia, blood aminotransferase bilirubin elevated alkaline phosphatase elevated, blood alkaline elevated, blood bilirubin phosphatase increased elevated, blood creatinine elevated Uncommon amylase increased blood bilirubin elevated, amylase elevated amylase elevated *Adverse reaction frequencies introduced in Table 2 will not be fully attributable to pembrolizumab alone however might include contributions from the underlying disease or from different medicinal products used in a mix. 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thyroiditis, adrenal c insufficiency c d Uncommon adrenal insufficiency, hypophysitis, d e e hypophysitis, thyroiditis thyroiditis, adrenal c insufficiency 12 Metabolism and nutrition problems Very widespread decreased urge for food hypokalaemia, decreased decreased appetite urge for food Common hyponatraemia, hyponatraemia, hypokalaemia, hypokalaemia, hypocalcaemia hyponatraemia, hypocalcaemia hypocalcaemia f f Uncommon sort 1 diabetes mellitus sort 1 diabetes mellitus type 1 diabetes mellitus Psychiatric issues Common insomnia insomnia insomnia Nervous system disorders Very frequent headache dizziness, headache, headache, dysgeusia neuropathy peripheral, dysgeusia Common dizziness, neuropathy lethargy dizziness, lethargy, peripheral, lethargy, neuropathy peripheral dysgeusia h Uncommon epilepsy epilepsy myasthenic syndrome g Rare Guillain-Barre syndrome, h myasthenic syndrome, i meningitis (aseptic), encephalitis Eye issues Common dry eye dry eye dry eye j j Uncommon uveitis uveitis Rare Vogt-Koyanagi-Harada syndrome Cardiac disorders пїЅ пїЅ пїЅ Common cardiac arrhythmia cardiac arrhythmia cardiac arrhythmia (including atrial (including atrial (including atrial fibrillation) fibrillation) fibrillation) ok Uncommon pericardial effusion, pericardial effusion myocarditis pericarditis k ok Rare myocarditis myocarditis, pericarditis Vascular problems Very frequent hypertension Common hypertension hypertension Respiratory, thoracic and mediastinal issues Very frequent dyspnoea, cough dyspnoea, cough dyspnoea, cough, dysphonia l l l Common pneumonitis pneumonitis pneumonitis Gastrointestinal problems Very common diarrhoea, belly diarrhoea, nausea, diarrhoea, stomach m m pain, nausea, vomiting, vomiting, constipation, pain, nausea, vomiting, m constipation belly ache constipation n n n Common colitis, dry mouth colitis, dry mouth colitis, dry mouth o o o Uncommon pancreatitis pancreatitis pancreatitis Rare small intestinal perforation Hepatobiliary disorders p Common hepatitis p p Uncommon hepatitis hepatitis Skin and subcutaneous tissue issues q r q r Very common rash, pruritus rash, alopecia, pruritus palmar-plantar erythrodysaesthesia q syndrome, rash, r pruritus 13 s s s Common severe skin reactions, extreme skin reactions, severe skin reactions, erythema, dry skin, erythema, dry skin dermatitis acneiform, t vitiligo, eczema, alopecia, dermatitis, dry pores and skin, dermatitis acneiform alopecia, eczema, erythema u Uncommon lichenoid keratosis, psoriasis, dermatitis hair colour adjustments, psoriasis, dermatitis, acneiform, dermatitis, lichenoid keratosis, t papule, hair colour adjustments vitiligo, eczema papule, psoriasis, t vitiligo Rare poisonous epidermal necrolysis, hair color adjustments, Stevens-Johnson syndrome, lichenoid keratosis, erythema nodosum papule Musculoskeletal and connective tissue disorders v v v Very frequent musculoskeletal pain, musculoskeletal pain, musculoskeletal pain, arthralgia arthralgia arthralgia, ache in extremity w w x Common pain in extremity, myositis, ache in myositis, arthritis, w x x y myositis, arthritis extremity, arthritis tenosynovitis y y Uncommon tenosynovitis tenosynovitis Renal and urinary issues z Common nephritis, acute kidney acute kidney injury, z harm nephritis z Uncommon nephritis General disorders and administration site situations aa Very common fatigue, asthenia, oedema, fatigue, asthenia, pyrexia, fatigue, asthenia, aa pyrexia oedema pyrexia aa Common influenza-like sickness, chills chills, influenza-like oedema, influenza-like sickness illness, chills Investigations Very common blood creatinine alanine increased aminotransferase elevated, aspartate aminotransferase increased, blood creatinine elevated Common aspartate aminotransferase hypercalcaemia, alanine blood alkaline elevated, alanine aminotransferase phosphatase elevated, aminotransferase elevated, increased, aspartate hypercalcaemia, blood hypercalcaemia, blood aminotransferase bilirubin elevated alkaline phosphatase elevated, blood alkaline elevated, blood bilirubin phosphatase increased elevated, blood creatinine elevated Uncommon amylase increased blood bilirubin elevated, amylase elevated amylase elevated *Adverse reaction frequencies introduced in Table 2 will not be fully attributable to pembrolizumab alone however might include contributions from the underlying disease or from different medicinal products used in a mix. 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